Mzimvubu to Keiskamma WMA, or Mzimvubu to Keiskamma Water Management Area (coded: 12), includes the following major rivers: the Swane River, Mntafufu River, Mzimvubu River, Mngazi River, Mthatha River, Xora River, Mbashe River, Nqabara River, Gqunube River, Buffalo River, Nahoon River, Groot Kei River and Keiskamma River, and covers the following Dams:
Primary drainage regions R and S, and also tertiary drainage regions T11 to T13, T20, T31 to T36, T60, T70, T80 and T90.