Murphy Cassone (born August 16, 2002) is an American tennis player.
Cassone has a career high ATP singles ranking of world No. 172 achieved on 18 August 2025.
Cassone played college tennis at Arizona State.
Cassone won his maiden ATP Challenger singles title at the 2024 Calgary National Bank Challenger. The following week he reached the semifinals at the 2024 Sioux Falls Challenger using a special exempt.
In July, Cassone made his ATP Tour debut as a qualifier at the Washington Open. He lost to Reilly Opelka in the first round.
In November, Cassone reached his second Challenger final at the Champaign Challenger, losing to Stefan Kozlov in the final.