Murchison is a peri-urban settlement in the Ugu District Municipality in KwaZulu-Natal, South Africa.
Murchison is located on the South Coast of KwaZulu-Natal, approximately 13 kilometres (8 mi) west of Port Shepstone. It borders the villages of Madakana, Mbotsha, Mdlanzi, Mtengwana and Boboyi.
Murchison is home to the Murchison District Hospital which is a 300-bed public hospital serving the surrounding rural district. The hospital was opened in 1943 by Mr D. Mitchell.
Murchison lies on the N2 national route roughly running E to W from Port Shepstone to Kokstad. It also connects to the other smaller towns in the hinterland of the South Coast including Ezinqoleni and Harding.