Motyginsky District () is an administrative and municipal district (raion), one of the forty-three in Krasnoyarsk Krai, Russia. It is located in the center of the krai and borders with Severo-Yeniseysky District in the north, Evenkiysky District in the northeast, Boguchansky District in the east, Taseyevsky District in the south, Kazachinsky District in the southwest, and with Yeniseysky District in the west. The area of the district is . Its administrative center is the urban locality (an urban-type settlement) of Motygino. Population: 19,140 (2002 Census); The population of Motygino accounts for 36.4% of the district's total population.
The district is located in the Angara River valley.
The district was founded on July 1, 1931.
As of 2013, the Head of the district and the Chairman of the District Council is Vladimir A. Funk.