Mossy Creek is a stream in Benton County in the U.S. state of Missouri. It is a tributary to the Osage River within the Lake of the Ozarks.
The stream headwaters arise just east of Missouri Route M at and about two miles west-northwest of the community of Hastain. The stream flows north then east paralleling Route M to its confluence with the Osage south of Lakeview Heights at .
Mossy Creek was so named on account of wetlands along its course.