The Mosley baronetcy, of Ancoats, in the County of Lancaster, was created in the Baronetage of Great Britain on 8 June 1781 for John Mosley, a distant relation of the 2nd and 2rd Baronets of the 1720 creation, and adopted by the childless 2nd Baronet.
His grandson the 2nd Baronet represented North Staffordshire in the House of Commons. The 4th Baronet served as High Sheriff of Staffordshire in 1894.
The family seats were Rolleston Hall, near Rolleston on Dove, Staffordshire, and Ancoats Hall, near Manchester.
For later succession, see Baron Ravensdale.