Montopoli in Val d'Arno is a comune (municipality) in the Province of Pisa in the Italian region Tuscany, located about southwest of Florence and about east of Pisa.
Montopoli in Val d'Arno borders the following municipalities: Castelfranco di Sotto, Palaia, Pontedera, San Miniato, Santa Maria a Monte.
It is home to a tower and an arch named after Castruccio Castracani, once belonging to a castle. Outside of town is the Franciscan Sanctuary of the Madonna di San Romano and the parish church of Santa Maria Novella.