Montelupone is a comune (municipality) in the Province of Macerata in the Italian region Marche, located about south of Ancona and about northeast of Macerata.
Montelupone borders the following municipalities: Macerata, Montecosaro, Morrovalle, Potenza Picena, Recanati. It is one of I Borghi più belli d'Italia ("The most beautiful villages of Italy").