Monteleone di Fermo is a comune (municipality) in the Province of Fermo in the Italian region Marche, located about south of Ancona, about north of Ascoli Piceno and of Fermo. As of 31 December 2004, it had a population of 449 and an area of .
Monteleone di Fermo borders the following municipalities: Belmonte Piceno, Monsampietro Morico, Montelparo, Santa Vittoria in Matenano, Servigliano.
Among the churches in the town are the following: