Mokete Reuben Tsotetsi (born 14 November 1982) is a South African international soccer player who plays as a central defender.
Born in Boipatong, Tsotetsi has played for Wits University, FC Sporting, Jomo Cosmos, Kaizer Chiefs, Bloemfontein Celtic, Vasco da Gama, Mpumalanga Black Aces and Roses United.
He earned one cap for South Africa, which came in a FIFA World Cup qualifying match against Sierra Leone on 14 June 2008.