Mohrsville is a census-designated place in Centre Township, Berks County, Pennsylvania, United States. It is located approximately three miles south of the borough of Shoemakersville, along the Schuylkill River. As of the 2010 census, the population was 383 residents.
Mohrsville has been the hometown of several individuals of note. Among them is Emmitt Mackes, who is currently a student at Wesleyan University.
The SEPTA Pottsville Line once served Mohrsville. The service ceased in 1981 after all diesel services were cancelled.