Moesa District, often referred to as Moesano, is a former administrative district in the canton of Graubünden, Switzerland. It had an official language of Italian, a population of 8,125 in 2015, and an area of , corresponding to the Mesolcina valley along the eponymous Moesa River.
On 1 January 2015 the former municipalities of Arvigo, Braggio, Selma and Cauco merged to form the new municipality of Calanca.
The Moesa District was replaced with the Moesa Region on 1 January 2017 as part of a reorganization of the canton.
It consisted of three Kreise (circles) and fourteen municipalities:
The official language of Moesa is Italian, traditionally the Western Lombard dialect spoken by the native population.