is a passenger railway station located in the town of Saka, Aki District, Hiroshima Prefecture, Japan. It is operated by the West Japan Railway Company (JR West).
Mizushiri Station is served by the JR West Kure Line and is 79.3 kilometers from the terminus of that line at .
The station consists of one ground-level island platform connected by a footbridge to a simple station building with automatic ticket machines. The station is unattended.
Mizushiri Station was opened on 7 February 1999.
In fiscal 2019, the station was used by an average of 69 passengers daily.
The station building is sandwiched between the sea on the west side and the mountains on the east side, and there is little flat land. There is a sandy beach called Bayside Beach on the west side of the station.