Miyankuh-e Sharqi Rural District () is in Afrineh District of Mamulan County, Lorestan province, Iran. Its capital is the village of Zirtang-e Chameshk.
During the 2006 National Census, the rural district's population (as a part of Mamulan District in Pol-e Dokhtar County) was 4,907 in 1,038 households. There were 4,250 inhabitants in 1,074 households at the 2011 census. The 2016 census measured the population of the rural district as 3,746 in 1,046 households. The most populous village among the district's 46 villages was Qaleh Nasir, with 384 people.
In 2023, the district was separated from the county during the establishment of Mamulan County, and the rural district was transferred to the new Afrineh District.