Route 111 is a highway in northwestern Missouri. Its northern terminus is at U.S. Route 136 in Rock Port; its southern terminus is at U.S. Route 59 in Oregon. The entire length of Route 111 is part of the Lewis and Clark Trail.
Commencing in Oregon in Holt County, the highway travels west, from its southern terminus, out of town to Forest City. Afterward, Route 111 follows the western edge of the Loess Bluffs northwest for where it junctions with U.S. Route 159 (US 159) and enters the Missouri River Valley. It runs concurrently with US 159 west for around passing Fortescue to the south, then turns north just southeast of Big Lake. The highway continues along the east side of Big Lake and through the town of Big Lake for where it meets Route 118. The highway travels west for then north to the town of Craig, where Route 111 Spur begins.
Route 111 travels west from Craig before continuing northwesterly towards Corning. Around here is where Route 111 is closest to the Missouri River, being only east at a point. The highway passes by the national historic place, St. JohnâÂÂs Evangelical Lutheran Church, in Corning Missouri. Leaving Corning, the highway travels northwesterly, exiting Holt County, Missouri after .
Entering Atchison County, Route 111 travels northwest before curving right and travels northerly another . The highway crosses Interstate 29 (I-29) at exit 107 and continues north-northeast up the Loess Bluffs towards Rock Port. The highway travels through Rock Port as Main Street and meets its northern terminus with US 136.
Missouri Route 1-F, which travelled west from Oregon to Forest City, was the first state-managed portion of what is now Route 111. A couple of years later, further portions of highway were state-maintained, such as between Forest City and Napier and between Craig and Corning. By 1929, Route 1-F was graveled, and by 1930, that same 1-F was designated as Route 118, while Route 111 was designated as the roadway between Mound City and Bigelow. By the late 1930s, these designations were inverted to what they are today.
In 1932, US 275 was fully paved and traversed the major towns of Atchison and Holt counties, leaving the prospects and purpose of what would become Route 111 diminished. Nevertheless, by 1934, the portion from Oregon to Forest City was paved, and the supplemental Route E was formed between Rock Port and Langdon, Missouri; the northeastern half of this route would later become part of Route 111. By 1935, the route extended from Forest City to Fortescue and past the newly-formed Big Lake State Park. The next year, Routes 111 and 118 finally met at the current western terminus of Route 118, west of Bigelow. By 1937, the entire present-day Route 111 consisted of state-maintained roads, with the addition of a few more supplemental routes connecting between Craig and Rock Port. Finally, by 1938, Route 111 was one complete roadway spanning the two county seats, Oregon and Rock Port.
Spur Route 111 is a spur route which connects to US 59. It lies entirely within the city of Craig.