Missouri's 27th Senatorial District is one of 34 districts in the Missouri Senate. The district has been represented by Republican Jamie Burger since 2025.
The district is based in Southeast Missouri and includes all of the counties of Bollinger, Cape Girardeau, Madison, Mississippi, Perry, and Scott. Major municipalities in the district include Cape Girardeau, Sikeston, Jackson, Perryville, Charleston, Scott City, and Fredericktown. The district is also home to Southeast Missouri State University.
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