Missouri's 21st Senatorial District is one of 34 districts in the Missouri Senate. The district has been represented by Republican Kurtis Gregory since 2025.
The district includes northern Clay, Cooper, Howard, Lafayette, Ray, and Saline counties. Major municipalities in the district include Excelsior Springs, Kearney, Liberty, Marshall, and Smithville, stretching between the Kansas City and Columbia metropolitan areas. The district is also home to the Missouri River, Smithville Lake, and Watkins Woolen Mill State Park.
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