The Mississippi County Courthouse for the Chickasawba District is located at 200 West Walnut Street in Blytheville, Arkansas, one of Mississippi County's two seats (the other is Osceola). It is a -story brick-and-cut-sandstone structure, designed by the Pine Bluff firm of Selligman and Ellesvard, and built in 1919. It is a fine local example of Colonial Revival styling, with a recessed center entrance and a projecting modillioned cornice. The interior has had few alterations since its construction.
The building was listed on the National Register of Historic Places in 1996.