The Ministry of Health and Sanitation () is the health ministry of Sierra Leone. , the Health Minister is Dr. Austin H. Demby. Their offices are located on the fourth floor of the Youyi Building, Brookfields, Freetown.
, the Ministry of Health and Sanitation is engaged in a campaign against the Ebola virus epidemic in West Africa, in which Sierra Leone was one of the most seriously affected countries.
As part of a larger campaign to reduce Sierra Leone's maternal mortality rate, the ministry invested in the construction of the Paul E. Farmer Maternal Center of Excellence, a maternity hospital in Koidu, Kono District that opened in 2026. The facility contains the nation's first neonatal intensive care unit.