The Ministry of Foreign Relations () is Uruguay's government ministry responsible for planning, directing, and implementing the country's foreign policy and international relations. It oversees Uruguayan embassies, consular representatives, permanent missions to international organizations, and other state services abroad.
Commonly referred to as , it is headquartered in the historic Santos Palace, located in Central Montevideo. The current foreign minister is Mario Lubetkin, who has served since March 1, 2025 in the cabinet of Yamandú Orsi.
It is commonly referred to in Uruguayan media and diplomatic jargon as the Palacio Santos, after the historical building which since 1955 has housed the ministry (originally the residence of President Máximo Santos in the late 19th century). It is located in the Centro neighbourhood of Montevideo.
This building is one of the major historic structures in the Uruguayan capital, and has been the subject of prominent documentary publicity.