The Minister for Foreign Affairs is a government official responsible for overseeing the foreign policy and international diplomacy of Ghana. Currently Samuel Okudzeto Ablakwa, the minister is usually one of the most senior members of Cabinet. Under pre-1992 military regimes in Ghana, the title; minister has been replaced with commissioner or secretary.
During the government rule of Nana Akufo-Addo of the New Patriotic Party between January 2017 and January 2025, the ministry was combined with other portfolios to form the Ministry of Foreign Affairs and Regional Integration under Shirley Ayorkor Botchway. On 18 September 2025, the ministry awarded diplomatic passport to the following Ghanaians, Ibrahim Mahama, Wade Maya, Rocky Dawuni, Anita Erskine and Dentaa.