The minister of women, youth and persons with disabilities is the minister of the South African government with political responsibility for South Africa's Department of Women, Youth and Persons with Disabilities. Between 2014 and 2024, the ministry was located in the Presidency, making its holders ministers in the presidency.
The current minister is Sindisiwe Chikunga, who was appointed by President Cyril Ramaphosa on 30 June 2024.
On 10 May 2009, announcing his first-term cabinet, newly elected President Jacob Zuma announced the establishment of the Ministry of Women, Youth, Children and People with Disabilities. Its formation was the result of a policy resolution by delegates to the 52nd National Conference of the governing party, the African National Congress. The inaugural minister was Noluthando Mayende-Sibiya.