The deputy minister for Macedonia and Thrace () is the government minister in charge of Greece's Sub-Ministry of Macedonia and Thrace, part of the Ministry of the Interior.
The department originated in the old , which was renamed the Ministry of Macedonia and Thrace on 19 August 1988.
The ministry was abolished on 7 October 2009 and downgraded to a general secretariat within the Ministry of the Interior, but was re-established on 21 June 2012. On 27 January 2015, it was again demoted to a sub-ministry within the Ministry of the Interior.