Millers Run is a long 3rd order tributary to Chartiers Creek in Allegheny and Washington Counties, Pennsylvania.
According to the Geographic Names Information System, it has also been known historically as:
Millers Run rises in a pond about 2 miles southwest of Primrose, Pennsylvania and then flows east-northeast to join Chartiers Creek at about 0.25 miles northeast of Sygan Hill, Pennsylvania.
Millers Run drains of area, receives about 39.0 in/year of precipitation, has a wetness index of 332.89, and is about 52% forested.