The Miles River is a tidal river in Talbot County, Maryland. It is a tributary of the Eastern Bay and is thus part of the Chesapeake Bay watershed.
Miles River was originally called the St. Michaels River; it derives its name from Saint Michael, the patron saint of Colonial Maryland.
Its watershed area is , of which is open water, so it is 22% water. The predominant land use is agricultural with , or 52% of the land area.