Miles Branch is a long first-order tributary to Marshyhope Creek in Dorchester County, Maryland. For part of its length, this stream forms the boundary of Caroline and Dorchester Counties.
Miles Branch rises about southeast of Federalsburg, Maryland in Caroline County and then flows generally northwest to join Marshyhope Creek in the southeast end of Federalsburg, Maryland.
Miles Branch drains of area, receives about 44.6 in/year of precipitation, and is about 13.57% forested.