Milanlu Rural District () is in the Central District of Esfarayen County, North Khorasan province, Iran. Its capital is the village of Parkanlu.
At the time of the 2006 National Census, the rural district's population was 3,936 in 891 households. There were 3,293 inhabitants in 911 households at the following census of 2011. The 2016 census measured the population of the rural district as 3,904 in 1,151 households. The most populous of its 46 villages was Ordaghan, with 767 people.