The Midwestern State Mustangs (also MSU Texas Mustangs) are the athletic teams that represent Midwestern State University, located in Wichita Falls, Texas, in NCAA Division II intercollegiate sports. The Mustangs compete as members of the Lone Star Conference for 13 varsity sports.
In 2017, Charlie Carr retired, replaced by athletic director, Kyle Williams.
In 2015, Brenna Moore won the NCAA Division II individual women's golf championship.