Midwest Pandemic is Twelve Tribes's third and final full-length album. They continue to follow the same style as their previous albums by using different or complex time signatures instead of common time.
The album was rated 3.5 out of five stars by Eduardo Rivadavia of AllMusic, who wrote that "Twelve Tribes manage to convey a powerful impact without the bombastic approach normally relied upon by many of their peers -- and that's yet another signal of their talent."
A music video was produced for the track "Muzzle Order".