The Middle River is a stream in southwest Callaway County of central Missouri. It is a tributary to the Missouri River.
The stream headwaters arise at approximately east of Millersburg at an elevation of approximately . The stream flows generally south-southeast passing about west of Fulton and passes under US Route 54 southwest of Fulton. It continues to the south-southeast and passes under Missouri Route 94 and into the Missouri River floodplain east of Tebbetts. The stream then meanders to the northeast for about before entering the Missouri River south of Mokane at and an elevation of .