Middle Branch Verdigre Creek is a long fourth-order tributary to Verdigre Creek in Knox County, Nebraska.
According to the Geographic Names Information System, it has also been known historically as:
Middle Branch Verdigre Creek rises on the Elkhorn River divide about 5 miles north-northeast of Page, Nebraska in Holt County and then flows northeast into Knox County and east to join Verdigre Creek about 3 miles southwest of Verdigre, Nebraska.
Middle Branch Verdigre Creek drains of area, receives about 25.68 in/year of precipitation, has a wetness index of 495.92, and is about 4.14% forested.