Michele Anaclerio (born 15 May 1982) is an Italian former professional footballer who played as a centre-back.
A youth product of A.S. Bari, Anaclerio made his Serie A debut on 27 May 2001 for Bari against Reggina Calcio, in Bari's third-last Serie A match of the season, since the club were in last place and had already mathematically been relegated.
On 30 March 2004, he played for the Serie B U21 Italian selection against Belgium U21.
In December 2017, Anaclerio joined Omnia Bitonto. After spells with Corato Calcio and U.S. Bitonto in Serie D, Anaclerio joined Molfetta Calcio at the end of August 2019.