Mice and Men is a lost 1916 American silent romance film directed by J. Searle Dawley, starring Marguerite Clark, and based on a 1901 Broadway play, Mice and Men by Madeleine Lucette Ryley.
In Virginia, Mark Embury, a rich man, having made desperate attempts to find a wife, decides to raise a young girl he has adopted, Peggy, in order to marry her. But she falls in love with George Lovell, Embury's nephew.
The film was praised in reviews in The Moving Picture World and Motion Picture News.