Mezzegra is a former comune (municipality) in the Province of Como in the Italian region Lombardy. Since 21 January 2014 it is part of the comune of Tremezzina.
It lies on the northwestern shore of Lake Como between Tremezzo and Lenno at the foot of Monte Tremezzo, elevation above sea level. It is about north of Milan and about northeast of Como. As of 31 December 2004, it had a population of 1,016 and an area of .
Mezzegra borders the following municipalities: Grandola ed Uniti, Lenno, Tremezzo.
The Comune di Mezzegra will be united to Lenno, Ossuccio and Tremezzo to form a single municipality named Tremezzina: the new administration will be formalized after election of the mayor on 25 May 2014
On 28 April 1945 in Giulino, a frazione of Mezzegra, Benito Mussolini and his lover Claretta Petacci were executed by communist partisans.