Mezzanego () is a comune (municipality) in the Metropolitan City of Genoa in the Italian region Liguria, located about east of Genoa.
The town is situated on the river Sturla in a valley of the same name. The distance to the Ligurian capital Genua is about .
Mezzanego borders the following municipalities: Borzonasca, Carasco, Ne, San Colombano Certénoli, Tornolo.