Mexico has participated in every edition of the Pan American Games since 1951, obtaining 40 medals (4 gold, 9 silver, and 27 bronze) in the first edition in Buenos Aires. In addition, the country is the first, and so far only one, to have hosted three editions of the games, two in Mexico City in 1955 and 1975, and one in Guadalajara in 2011.
Overall, Mexican athletes have won 1,289 all-time medals at the Pan American Games. The best participation of a Mexican delegation has been at the 2023 Pan American Games in Santiago, Chile with 142 medals (52 gold, 38 silver, and 52 bronze). The country has always been inside the top-6 of the medals table, managing a third place overall in the 1955 Pan American Games and achieving fourth place 8 different times. Individually, diver Paola Espinosa is the most decorated Mexican athlete at the Pan American Games, obtaining 15 medals (8 gold, 3 silver, and 4 bronze) in her career.
Red border indicates host nation status.
As of the conclusion of the 2023 Pan American Games.
Mexico participated in the first, and so far, only edition of the Winter Pan American Games in 1990 in Argentina. Mexico sent 4 athletes and only 8 countries participated. The competition was limited to 3 alpine skiing events due to the lack of snow. The following edition in 1993 was cancelled after the United States refused to compete without a full schedule of events, and the Winter Pan American Games have never been held again.
In 2019, Panam Sports created the Junior Pan American Games for athletes 21 years of age or younger in order to bridge a gap between junior and senior-level sports. Mexico has participated in both editions of the games.
Red border colour indicates host nation status.