Merkezefendi () is a municipality and district of Denizli Province, Turkey. Its area is 336 km<sup>2</sup>, and its population is 336,818 (2022). The district was established as a result of the 2013 local government reorganisation from part of the former central district of Denizli. Another part of the former central district was added to the Pamukkale District. The name of the district refers to the 16th-century Sufi Merkez Efendi.
There are 50 neighbourhoods in Merkezefendi District:
Merkezefendi Belediyesi Denizli Basket represents Merkezefendi andÃÂ DenizliÃÂ in Turkish Basketball Super League (BSL).