Mendon Presbyterian Church is a historic Presbyterian church located at Mendon in Monroe County, New York.
The building is an eclectic Gothic Revival style building constructed in 1900. Its interior features a "Combination Church Plan" incorporating a meeting room with the main auditorium separated by a set of large folding doors.
The building was listed on the National Register of Historic Places in 2005.
The congregation moved to a new building on Cheese Factory Road in the Town of Mendon in 2006, and merged with Centerway Church in 2023.