Melipilla Province () is one of six provinces in the Santiago Metropolitan Region of central Chile. The provincial capital is the city of Melipilla.
As a province, Melipilla is a second-level administrative division of Chile, governed by a provincial delegate who is appointed by the president. The current delegate is Sandra Saavedra, who was appointed by president Gabriel Boric.
The province comprises five communes (Spanish: comunas), each governed by a municipality consisting of an alcalde and municipal council:
The province spans an area of , the second largest in the Santiago Metropolitan Region. According to the 2002 census, Melipilla was the fifth most populous province in the region with a total population of 141,165. At that time, there were 80,790 people living in urban areas, 60,375 living in rural areas, 71,595 men, and 69,570 women.