Mehregan District () is in Saravan County, Sistan and Baluchestan province, Iran. Its capital is the city of Esfandak, whose population at the time of the 2016 National Census was 2,962 people in 725 households.
In August 2017, Kuhak-e Esfandak Rural District was separated from Bam Pasht District in the formation of Mehregan District. In November 2021, the village of Esfandak was elevated to the status of a city.