Mehoopany is an unincorporated community in Wyoming County, Pennsylvania, United States. The community is located along Pennsylvania Route 87, south of Meshoppen. Mehoopany has a post office with ZIP code 18629.
The earliest settlements in Mehoopany were located in the "Vaughn's Bend" and "Grist Flat". Vaughn's Bend was first settled by a veteran of the American Revolutionary War named Henry Love shortly after its end. Meanwhile, the Grist Flat was settled later on in an unknown period by a man named Grist.
The first house supported by a frame building was built by a man known as David Jayne in the year 1806.
The town was laid out in 1818.
The United States Census Bureau defined Mehoopany as a census designated place (CDP) in 2023.
The population in 2025 was 884.