Megaphobema is a genus of tarantulas that was first described by Reginald Innes Pocock in 1901. They look similar to members of Pamphobeteus except for its legs; the third and fourth pairs of legs are much larger and stronger than the first two pairs.
Its described species are found in Ecuador, Brazil, Colombia, Costa Rica and Peru.
, this genus includes four species:
M. mesomelas and M. peterklaasi were transferred to the new genus Abdomegaphobema in 2023.