Mean kinetic temperature

In the pharmaceutical industry, Mean kinetic temperature (MKT) is a calculated temperature that represents the equivalent thermal effect of temperature variations over time, such that the degradation occurring under fluctuating conditions is equal to that which would occur at a constant MKT value.

The mean kinetic temperature can be expressed as:

Where:

is the mean kinetic temperature in kelvins

is the activation energy (in kJ mol^{−1})

is the gas constant (in J mol^{−1} K^{−1})

to are the temperatures at each of the sample points in kelvins

to are time intervals at each of the sample points

When the temperature readings are taken at the same interval (i.e., = = = ), the above equation is reduced to:

Where:

is the number of temperature sample points

Reference