Meadow Run is a long 4th order tributary to the Youghiogheny River in Fayette County, Pennsylvania.
According to the Geographic Names Information System, it has also been known historically as:
Meadow Run rises about northeast of Washington Springs, Pennsylvania, and then flows southeast and northeast to join the Youghiogheny River at Ohiopyle.
Meadow Run drains of area, receives about per year of precipitation, has a wetness index of 376.51, and is about 82% forested.