Meadow Run is a long 2nd order tributary to Jacobs Creek in Westmoreland County, Pennsylvania.
Meadow Run rises about 1.5 miles southwest of Ruffsdale, Pennsylvania, and then flows southwest to join Jacobs Creek about 0.75 miles west-northwest of Chaintown.
Meadow Run drains of area, receives about 42.3 in/year of precipitation, has a wetness index of 379.72, and is about 40% forested.