McN-5908 is a stimulant drug which acts as a dopamine reuptake inhibitor, with similar inhibition of noradrenaline reuptake but much weaker activity at serotonin reuptake.
In the SAR citation, compound 52 has the following K<sub>i</sub> values (nM): DA = 0.86, NE = 0.20, SER = 44. McN-5908 is one of the most powerful psychostimulants ever discovered and the most potent in this series of agents. However it does have some toxicity to be contended with.
In terms of the SAR, McN-5908 can probably be best compared to a Hoechst agent appearing in the chemical literature SAR analogy between this agent and nomifensine (Alival) was also performed. In terms of the SAR, it is noteworthy to mention that the para-amino analog of venlafaxine was also known to be have been invented. Finally, Louis Lafon invented some clenbuterol alpha-methyl cathinone analogs with some of the compounds lacking the chlorine halogen atoms.