McIntire Run is a long 2nd order tributary to Big Sandy Creek in Fayette County, Pennsylvania.
McIntire Run rises about 2 miles south of Summit, Pennsylvania, and then flows southeast to join Big Sandy Creek about 3 miles north-northeast of Elliottsville.
McIntire Run drains of area, receives about 51.2 in/year of precipitation, has a wetness index of 313.93, and is about 95% forested.