McDesme is a rural locality in the Shire of Burdekin, Queensland, Australia. In the , McDesme had a population of 254 people.
The locality is bounded to the north and north-east by Kilne Road, to the south by the Burdekin River, to the south-west and west by Plantation Creek, and to the north-west by Robertson Road and Webber Road.
The Bruce Highway enters the locality from the south (Home Hill across the river via the Burdekin Bridge) and exits the locality to the north (Ayr).
The North Coast railway line also enters the locality from the south (Home Hill across the river via the Burdekin Bridge) and exits to the north (Ayr). There are three now-abandoned railway stations on the line within the locality:
The land use is predominantly growing sugarcane. There is a network of cane tramways to transport the harvested sugar cane to the Pioneer Sugar Mill.
The Marali railway station was named on 9 November 1917. Marali is an Aboriginal word meaning tomorrow.
McDesme Provisional School opened in 1905. On 1 January 1909, it became McDesme State School. It closed circa 1964. The school was on a site on the south-east corner of McDesme Road and Old Home Hill Road ().
The Inkerman Bridge across the Burdekin River to Home Hill officially opened on 8 September 1913. The bridge carried the North Coast railway line. As the nearest road bridge across the river was upstream, a low-level road bridge was built across the river () in 1929 and was completed in January 1930 and within two weeks was under water due to the river flooding. Due to the frequent flooding of the river, the rail and road bridges were often closed or damaged, leading to the decision to build a single higher-level road-and-rail bridge. Due to the lack of rock in the sandy soil to use as foundations, for many years it was not believed possible to build a high-level bridge across the Burdekin River. However, by copying construction techniques used in India for sand-footing bridges, work began on the Burdekin Bridge (also known as the Silver Link) in April 1947 but it was not operational until 27 March 1957. The new bridge was upstream of the Inkerman Bridge. The Burdekin Bridge officially opened on 15 June 1957. At , the Burdekin Bridge is one of the longest multi-span bridges in Australia and the only one in Australia without a firm footing. Some pylons of the Inkerman Bridge are still visible.
In the , McDesme had a population of 277 people.
In the , McDesme had a population of 254 people.
There are no schools in McDesme. The nearest government primary schools are:
The nearest government secondary schools are Ayr State High School in Ayr and Home Hill State High School in Home Hill.
There are also non-government schools in Ayr and Home Hill.