McClelland-Layne House is a historic home located at Crawfordsville, Indiana. It was built in 1869, and is a two-story, L-shaped, Italian Villa style brick dwelling. It has a low-hipped roof and segmental- and round-arched windows. The house features a three-story tower topped by a low-hipped roof. It was built for well known Crawfordsville surgeon Dr. James S. McClelland.
It was listed on the National Register of Historic Places in 1985.