Mayo-Kebbi Ouest () is one of the 23 provinces of Chad. Its capital is Pala. It is composed of the southern areas of the former prefecture of Mayo-Kebbi (sub-prefectures of Pala and Léré).
The province borders Mayo-Kebbi Est Region to the north-east, Tandjilé Region to the east, Logone Occidental Region to the south-east, and Cameroon to the west and north-west. The Mayo Kébbi river flows through the north the province, with Lake Léré and the smaller Lake Tréné located in the north-west.
Pala is the capital of the province; other major settlements include Binder, Guégou, Lagon, Lamé, Léré and Torrock.
As per the 2009 Chadian census, Mayo-Kebbi Ouest had 564,470 inhabitants. The main ethnolinguistic groups are the Fula, Gidar, Mangbai, Mundang, Ngeté-Herdé peoples, Peve, Sara groups such as the Ngambay, and Tupuri.
The province of Mayo-Kebbi Ouest is divided into four departments: